Reaction between antineoplastic nitidine chloride and sodium hydroxide solution
- VernacularTitle:抗肿瘤剂氯化两面针碱在碱溶液中的反应
- Author:
Hongqin YANG
;
Weiqin WAN
;
Yun ZHOU
;
- Publication Type:Journal Article
- Keywords:
nitidine chloride;
sodium hydrox
- From:
Academic Journal of Second Military Medical University
2000;0(08):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To challenge the previously proposed anticancer mechanism of nitidine chloride, which suggest there exist anti tumor C(6)=N(5) double bond structure. Methods: An antitumor alkaloid, nitidine chloride, was treated in aqueous sodium hydroxide solution without the presence of certain kinds of amino acids and oxygen. Results and Conclusion: It had been revealed that virtually equal amount of 5, 6 dihydronitidine and oxynitidine was produced under such circumstances. The results suggest the anticancer mechanism of nitidine chloride need further investigation. [
