Clinical Consideration of Obese Infertile Women.
- Author:
Yoon Sung NAM
;
Chang Jin JEONG
;
Nam Keun KIM
;
Tae Ki YOON
;
Kwang Yul CHA
- Publication Type:Original Article
- Keywords:
Obesity;
Infertility
- MeSH:
Body Weight;
Dehydroepiandrosterone Sulfate;
Diabetes Mellitus;
Female;
Glucose;
Humans;
Hyperandrogenism;
Hyperinsulinism;
Incidence;
Infertility;
Insulin;
Insulin Resistance;
Obesity;
Plasminogen Activator Inhibitor 1;
Plasminogen Activators;
Testosterone;
Thrombophilia
- From:Korean Journal of Fertility and Sterility
2002;29(3):209-214
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To analyze the clinical characteristics of obese infertile women. MATERIAL AND METHOD: Height, weight, body mass index, menstrual pattern, glucose, insulin, glucose / insulin ratio, dehydroepiandrosterone sulfate (DHEA-S), testosterone, free testosterone and plasminogen activator inhibitor (PAI-1) of 15 obese infertile women were tested. RESULTS: Of 15 obese infertile women, the number of diabetes mellitus, hyperinsulinemia, and insulin resistance was 2 (13%), 2 (13%), 2 (13%), respectively. The incidence of increased DHEA-S, testosterone, and free testosterone was 7 (47%), 1 (7%), 6 (40%), respectively. Notably, all patients showed increased PAI-1. CONCLUSIONS: Obesity is associated with infertility as well as many kinds of health problems. Obesity is closely related to insulin resistance and it also causes hyperandrogenism. Increased PAI-1 is one of the important causes of thrombophilia. Consequently, in the workup of obese infertile patient, many aspects of health problems should be considered.
