Effects of doxazosin in treatment of mild to moderate essential hypertension
- VernacularTitle:甲磺酸多沙唑嗪片治疗轻中度原发性高血压的临床试验
- Author:
Zonggui WU
;
Gaozhong HUANG
;
Rongzeng DU
;
- Publication Type:Journal Article
- Keywords:
doxazoxin;
hypertension
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To investigate the effect of doxazosin on mild to moderate essential hypertension. Methods: A prospective, randomized, double blind study was carried out in 80 patients with hypertension. Forty patients were randomly given doxazosin (doxazosin group) or terazosin (control group) for 8 weeks. The others 40 were given doxazosin (open group), 10 of them for 6 months. Results: BP decreased significantly after administration of both doxazosin and terazosin, and reached its peak at week 4. The effect continued at the end of experiment. HR was slightly increased. In open group, the results was similar and the total effective rate was 90.0%. There were no significant changes in liver and renal functions and electrocardiography. The incidence of adverse effects like dizziness, palpitation and somnolence in doxazosin group was 30.0% . No significant difference between doxazosin and control group was found. Conclusion: Doxazosin has stable hypotensive effect and the patients compliance is good.
