Effects of herbimycin A on proliferation and nitric oxide production stimulated by interleukin 1 in chondrocytes
- VernacularTitle:杀莠素A对兔软骨细胞增殖和产生NO的影响
- Author:
Jiesong WANG
;
Junping ZHANG
;
Min ZHANG
;
Dinghua QIAN
;
- Publication Type:Journal Article
- Keywords:
herbimycin A;
chondrocytes;
IL 1;
proliferation
- From:
Academic Journal of Second Military Medical University
1985;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective: To study the effects of herbimycin A on proliferation and NO production stimulated by IL 1 in chondrocytes. Methods: IL 1 alone or in combination with herbimycin A was administered.Chondrocytes proliferation was detected by crystal violet dying method and NO production was detected by Griess method. Results: IL 1 inhibited chondrocytes proliferation. Herbimycin A dose dependently reversed the effect. Also herbimycin A could inhibit NO production induced by IL 1. Conclusion: The reversing effect of herbimycin A on chondrocytes proliferation may be mediated by NO.
