Protective effects of allopregnanoloneagainst different seizure models in mice
- VernacularTitle:四氢孕酮对小鼠不同惊厥模型的保护作用(英文)
- Author:
Rong YU
;
Ming-Hui YAO
;
- Publication Type:Journal Article
- Keywords:
allopregnanolone;
phenobarbital;
seizure;
maximal electrical seizure;
picrotoxin;
ED50
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To examine the protective effects of allopregnanolone against seizure on different animal models.Methods The protective effects of allopregnanolone against maximal electrical seizure (MES) and picrotoxin-induced seizure were studied in C57 mice 15 minutes after vehicle or drug intraperitoneal administration.Results In the MES test, we found that pretreatment with the phenobarbital or allopregnanolone produced a dose-dependent protective effect against seizure. The potency (ED50 value) of phenobarbital in the MES test was 2.40 mg?kg-1, with 95% confidence interval range from 1.22 to 4.72 mg?kg-1. The potency (ED50 value) of allopregnanolone in the MES test was 0.086 mg?kg-1, with 95% confidence interval range from 0.037 to 0.201 mg?kg-1, which was significantly higher than that of phenobarbital (P
