Effect of human placental extracton the lipoprotein-cholesterol metabolism
- VernacularTitle:胎盘提取液影响脂蛋白-胆固醇代谢的实验研究
- Author:
Wen-Ji CUI
;
Jing-Wen YANG
;
Zhong-Zhi LV
;
- Publication Type:Journal Article
- Keywords:
human placental extract;
lipoprotein-cholesterol metabolism;
liperoxide;
superoxide dismutas;
6-keto-PGF1?;
platelet aggregates
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim The effect and mechanism of human placental extract(HPE) on the lipoprotein-cholesterol metabolism, peroxidation and the function of platelet aggregation in hyperlipaemia rats were abserved.Methods Wistar rat with hyperlipaemia models were given each HPE 0.4 ml (100 g)-1?d-1 through lavage for 12 days.The serum levels of TG,TC,LDL-C,HDL-C and HDL2-C in its subgroup were measured.The activies of LPO and SOD in both blood and liver tissue were determined .The effect of HPE on lipidosis of liver were abserved by fat dyeing.The levels of 6-keto-PGF1?,TXB2 in plasma and maximum platelet aggregation rate were measured by ELASA. Result The levels of HDL-C and HDL2-C were increased (P
