Mornitoring of the enantiomers of (?) -trans tramadol andits active metabolite in the serum of postoperative patients afterdifferent intravenous doses of (?)-trans tramadol hydrochloride injection
- VernacularTitle:术后病人静滴不同剂量盐酸反式曲马多后血清中母体药物及活性代谢物对映体监测
- Author:
Hui-Chen LIU
;
Yan-Yan YANG
;
Yan-Ning HOU
;
Ya-Li WANG
;
- Publication Type:Journal Article
- Keywords:
?-trans tramadol;
(?)-trans O-demethyltramadol;
analgesic effect;
adverse reaction;
high performance capillary electrophoresis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the relationship between the clinical actions and the serum concentrations of the enantiomers of (?)-trans tramadol and its active metabolite. Methods 20 postoperative patients were divided into two groups and given multiple intravenous doses of (?)-trans tramadol hydrochloride injection, 400 mg?d-1 (group A) or 300 mg?d-1 (group B). The blood samples were taken at 38 h after the initial dose. The concentrations of the enantiomers of (?)-trans tramadol and its active metabolite, (?)-trans O-demethyltramadal were determined with high performance capillary electrophoresis(HPCE). Results The concentrations of the enantiomers of (?)-trans tramadol, the frequency and serious level of adverse reactions were higher in group A than in group B. The concentrations of the enantiomers of (?)-trans O-demethyltramadal, the analgesic effect were similar between group A and group B. Conclusion There is much closer relation between the analgesic effect and the concentration of (+)-O-demethyltramadal. The frequency and serious level of adverse reactions may be attributed to the higher concentrations of the enantiomers of (?)-trans tramadol, which are caused by the saturated metabolism.
