Relative bioavailablity of cefaclor effervescent tabletsin human volunteers
- VernacularTitle:头孢克罗泡腾片的相对生物利用度
- Author:
Fu-Rong QIU
;
Jin-Mei JI
;
Bo CHENG
;
Zhao-Hong ZENG
;
Hua SUN
;
Guo-Guang MAO
;
- Publication Type:Journal Article
- Keywords:
cefaclor;
effervescent tablets;
relative bioavailability;
reversed phase-high performance liquid chromatographay
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To study relative bioavailablity of cefaclor effervescent tablets in healthy volunteers. Methods According to the crossover design, A volunteers were each orally given a single does of the 0.75 g cefaclor effervescent tablets and cefaclor capsules with an interval of 5 days between the two formulations.The plasma concentrations of the drug were determined by RP-HPLC.Pharmacokinetic parameters were obtained by ATPK programe,and calculated on the basis of open single compartment model.Results After a single oral dose, the peak levels in plasma averaged Cmax(31.27?5.81)?g?ml-1 and(30.56?5.25) ?g?ml-1 at (0.58?0.12)h and(0.73?0.17)h and AUC0～4(35.48?4.65) ?g?h?ml-1 and (35.89?2.90) ?g?h?ml-1 for tablet and capsule,respectively. Conclusion The result shows that two formulations are bioequivalence.
