Powdered injections of luotai protect against ISO-induced experimental myocardial ischemia model on rats
- VernacularTitle:洛泰对异丙肾上腺素诱导大鼠急性心肌缺血的保护作用
- Author:
Xiu-Ling LEI
;
Xue-Feng DONG
;
Leng LI
;
Zhi-He CHEN
;
- Publication Type:Journal Article
- Keywords:
powdered injections of luotai(consist of PNS);
isoproterenol(ISO);
rat;
myocardial ischemia;
electrocardiogram
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim Powdered injections of luotai consist of total saponins of panax notoginseng(PNS) which protect against ischemia injury from myocardial reperfusion injury.Methods ISO-induced acute myocardial ischemia model in rat was made, which decreased S-T sigments in ECG.Luotai after intravenous injection or oral can protect against S-T sigment significant reduction and ∑ST after ISO induced acute myocardial ischemia .Results Luotai 50 mg?kg-1 and 100 mg?kg-1 significantly inhibited S-T sigment decreases. Conclusion Luotai protect ISO induced acute myocardial ischemia and has dose-dependent effect.This ISO-induced acute myocardial ischemia model in rat has some significant advantages,for example,higher stability, good duplication, quickly filtrates, easily masters.
