Effect of anti-digoxin antiserum on endogenous digitalis-like factorand membrane ATPase activity in hypoxic injury myocardium
- VernacularTitle:地高辛抗血清对缺氧损伤心肌组织内源性洋地黄样因子和心肌细胞膜ATP酶活性的影响(英文)
- Author:
Yong_Sheng KE
;
Hao YANG
;
Ting YANG
;
Guang_Hua CHENG
;
You_Xia WANG
;
- Publication Type:Journal Article
- Keywords:
myocardium;
hypoxic injury;
endogenous digitalis_like factor;
Na+_K+_ATPase;
Ca2+_ATPase;
anti_digoxin antiserum
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To evaluate the protective effect of anti_digoxin antiserum on hypoxic injury myocardium and its mechanism. Methods It was observed that different concentration anti_digoxin antiserum effect on endogenous digitalis_like factor and cell membrane ATPase activity in hypoxic myocardium model. Results The level of endogenous digitalis_like factor was remarkably higher, cell membrane ATPase activity were remarkably lower in hypoxic group than those of normal group; anti_digoxin antiserum can resume membrane ATPase activity.Conclusion Rise of endogenous digitalis_like factor was basic of molecular biology of myocardial damage during myocardial hypoxia. Anti_digoxin antiserum has lightened myocardial injury and has protective effect on hypoxic myocardium by against effect of endogenous digitalis_like factor.
