Effect of ligustrazine on pulmonary arterial pressure and thromboxane A_2 and prostacyclin in chronic hypoxic hypercapnic rats
- VernacularTitle:川芎嗪对慢性低氧和高二氧化碳致大鼠肺动脉高压及TXA_2和PGI_2的影响
- Author:
Liangxing WANG
;
Shaoxian CHENG
;
Zhengjie XU
;
Linsheng YU
;
Yupeng XIE
;
Yanfan CHENG
;
Wen WANG
;
- Publication Type:Journal Article
- Keywords:
ligustrazine;
anoxia;
hypercapnia;
hypertension;
pulmonary;
thromboxane A2;
prostacyclin
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of ligustrazine on pulmonary arterial pressure,thromboxane A2(TXA2) and prostacyclin(PGI2) in chronic hypoxic hypercapnic rats.Methods Thirty rats were randomly divided into control group(A), hypoxic hypercapnic group(B) and hypoxic hypercapnia+ ligustrazine (lig) group (C) .Results The mPAP in group B was significantly higher than that in group A(P0.05) ; The specific value of WA/TA(vessel wall area/total area) and SMC (the density of medial smooth muscle cells) were significantly higher in group B than that in group A(P0.05).Conclusion Ligustrazine can inhibit pulmonary hypertension and structural remodeling of pulmonary artery in chronic hypoxic hypercapnic rats by inhibiting synthesis of TXA2.
