Effects of Taurine on dysfunction of myocardial nuclear calcium transport in rat myocardial injury induced with isoproterenol
- VernacularTitle:牛磺酸对大鼠心肌损伤时心肌细胞核钙转运功能异常的保护作用
- Author:
Fusheng WAN
;
Zhaojian ZENG
;
Xiaoman ZHAO
;
Daya LUO
;
- Publication Type:Journal Article
- Keywords:
myocardial injury;
Ca2+ transport;
nucleus;
taurin
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the dysfunction of myocardial nuclear calcium transport in rat myocardial injury and effects of taurine on it . Methods The model of myocardial damage was induced by subcutaneous injection of isoproterenol (ISO,5 mg?kg-1?d-1). Myocardial nuclei were purified with Sucrose density centrifugation and identified zymologically. The activity of Ca2+_ATPase was measured zymologically and calcium uptake was assayed with 45Ca2+ isotope.Results Compared with the control, the Ca2+_ATPase activity of myocardial nuclear in ischemia group was decreased by 18.1%(P
