Protective effect of total paeony glocoside against ischemia injury in cultured primary cortex neurons
- VernacularTitle:赤芍总甙对原代培养大鼠神经细胞损伤模型的保护作用
- Author:
Lina HE
;
Jun YANG
;
Subing HE
;
Jing WANG
;
Chao LIU
;
- Publication Type:Journal Article
- Keywords:
total paeony glycoside;
cortex neuron;
cerebral ischemia
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate protective effects and mechanism of TPG on ischemia_like injury models. Methods Six ischemia models including hypoxia, hypoglucose, oxidant injury, calcium overload, nitric oxide neurotoxicity and excitatory amino acid injury were used to assay the anti_ischemic roles of TPG in cultured primary cortex neurons. Results It was found that TPG possessed obvious protective effects on primary neurons in injury models by the way of morphological examination. Crystal violet staining also indicated that TPG increased number of life neurons in injury models significantly. Couclusions 50～200 ?g?ml-1 TPG protected rat cortex cells from all injury models effectively in vitro.
