Effect of the all trans retinoic acid and Ara-c on the telomerase activity of HL-60 cells
- VernacularTitle:全反式维甲酸和阿糖胞苷对HL-60细胞端粒酶活性的影响
- Author:
Xiang_Hua WU
;
Kai_He YE
;
Ai_Qun HU
;
- Publication Type:Journal Article
- Keywords:
HL_60 cell;
telomerase activity;
all trans_retinonic acid;
cytosire arabinoside
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the possible mechanism of human promyelocytic leukemia cells differentiation and apoptosis induced by all trans_retinoic acid (ATRA) and Ara_c. Methods The effects of ATRA and Ara_c on the tolomerase activity of HL_60 cells were detected by PCR_ELISA. Results The tolomerase activity of HL_60 cells declined during the course of differentiation and apoptosis induced by ATRA and Ara_c. Conclusion These findings suggest that ATRA and Ara_c can inhibit tolomerase activity of HL_60 cells. It may be one of the important mechanisms of human promyelocytic leukemia cells differentiation and apoptosis induced by ATRA and Ara_c.
