ICAM-1 expression in experimental fibrosistissue affected by Radis Astragali
- VernacularTitle:黄芪对实验性肝纤维化组织ICAM-1表达影响的免疫组化研究
- Author:
Yao_Jun WANG
;
Qi_Zhen QUAN
;
Zi-Qin SUN
;
Feng QI
;
Xue_Liang JIANG
;
Xiu_Li ZHANG
;
Dong WANG
;
- Publication Type:Journal Article
- Keywords:
Radis Astragali;
liver fibrosis;
therapy;
ICAM_1
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the antifibrotic effect of Radis Astragali and to explore the mechanism. Methods The fibrosis of animal model was induced with CCl4,and the model animals were treated with Radis Astragali in treatment group and saline in control group respectively. Results The serum hyaluronic acid (HA), fibrosis score and ICAM_1_positive hepatocytes all the decreased in the treatment group as compared to those in the control group.Conclusion Radis Astragali has satisfactory effect on experimental fibrosis. The mechanism may be correlated with its affection on ICAM_1 in liver tissue.
