Nasal absorption of furosemide and promotion action of l-menthol
- VernacularTitle:呋塞米的鼻腔吸收及薄荷醇的促进作用
- Author:
Hui WANG
;
Man_Qing XUE
;
- Publication Type:Journal Article
- Keywords:
furosemide;
In situ nasal recirculation method;
nasal absorption;
l_menthol
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim The nasal absorption of furosemide and promotion action of l_menthol was examined. Methods In situ nasal recirculation methods was used to study the does_effect relationship of nasal absorption of furosemide and the effect of l_menthol on nasal absorption of furosemide in rats. Results When the concentration of furosemide in circulation liquid was respectively(4.66?0.33) ?(9.76?0.45) and (18.83?1.89) ?g?ml-1,the absorption rate constant k(min-1) of nasal in situ was correspondingly 0.0067?0.0011,0.0134?0.0024 and 0.0163?0.0037;and urine liquid appearing time was (73.33?1.53)?(52.67?7.02) and (47.00?4.58) min.But the larger the concentration of l_menthol, the little the absorption rate constant k. Conclusion Furosemide can be absorbed through the nasal mucous, and l_menthol can promote its absorption.
