Effect of benazepril on mesangial matrix of adriamycin nephrotic rats
- VernacularTitle:苯那普利对阿霉素肾病大鼠系膜基质的影响
- Author:
Xuewang LI
;
Xianghua LU
;
Hongmei SONG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Angiotensin cnverting engyme inhibitor;
Adriamycin nephropathy;
Mesangial matrix
- From:
Chinese Journal of Nephrology
1997;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of angiotensin convening enzyme inhibitor (ACEI), benazepril, on the clinicohistological changes of normal and adriamycin nephrotic rats. Methods When proteinria was present for 2 weeks after injection of adriamycin, these rats were treated with saline、predsone、 amlodipine and benazepril. Urinary protein excretion was measured in 0, 3rd, 6th week after treatment. Mesangial cell index and mesangial matrix index were assessed in the 6th week. Moreover immunohistochenical stain for type Ⅳ collagen, fibronectin and laminin were performed before and after treatment, and RNA transcription of laminin was evaluated with slit hybridization. Results Proteinuria of benazepril-treated rats was significantly reduced after 6-week treatment compared with those before treatment[ (44 .7 ? 6.0)mg／２４h vs(56.8 ?23 .4)mg/24h. The proliferation of mesangial cells and the synthesis of mesangial matrix were inhibited in the benazepril-treated rats. Similar results were achieved in the predisone-treated rats, but not in amlodipine-treated rats. Conclusion Benazepril can sigificantly reduce the synthesis of mesangial matrix in adriamycin nephrosis rats by inhibiting RNA transcription.
