Experimental study of antibiotics and anticoagulants effection on mouse peritonaeum
- VernacularTitle:抗生素及抗凝药对小鼠腹膜影响实验研究
- Author:
Yi-Ling ZHANG
;
Jian-Wu TANG
;
Zhen-Bo DONG
;
Ya-Fang GUO
;
- Publication Type:Journal Article
- Keywords:
drug;
peritoneal dialysis;
peitoneal sclerosis
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim The effects of antibiotics and anticoagulants on mouse peritonaeum were ob-served to explore the factor of the peritoneal dialysis related sclerosing peritoni-tis. Methods The experimental models of peritoneal dialysis were established in miceby infusing different kind of drugs to the peritoneal cavity and the changes of the peri-toneal membrane for each drug at different time were observed by the autopsy and lightmicroscope for several weeks. Results Amikacin, Cefradine, Zinacef, Ciprofloxacin,Heparin and Urokinase could induce sclerosing changes of peritoneal membrane such asloss of peritoneal mesothelum infiltration of inflammatory cells and of proliferation fibrecell.These changes were irreversible after the drugs were stoped.Conclusion Thedrugs commonly used in peritoneal dialysis may in different degree result in peritonealsclerosis.
