Timed analgesic effects by butabital, acetaminophen and caffeine in combination in mice and rats~1
- VernacularTitle:布他比妥,醋氨酚和咖啡因的联合镇痛作用及其历时性变化
- Author:
Hui-Jie YANG
;
Qing-Shan ZHENG
;
- Publication Type:Journal Article
- Keywords:
acetaminophen;
butabital;
caffeine;
combination drug therapy;
analgesic effect
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To observe the timed analgesic effects by butabital (B), acetaminophen(A) and caffeine (C) in combination (BAC), in which the proportion was fixed as1. 25∶ 8. 1∶1. Method Three types of experimental methods, including the tailflicking method, the hot plate method and the pressurizing tail method, weretaken to determine indices at different times after the animals were adminstered(ig) high, median and low BAC dose. Results and conclusion BAC had a stronganalgesic effect in three types of experiments. The effect began 30 min after ad-ministration, arrived maximum at 1 h, decreased at 2 h and disappeared at 4 h.There was a dose-effect relationship between large and little BAC dose.
