Study of the antiulcer effect of pantoprazole
- VernacularTitle:注射用潘托拉唑钠抗实验性急性胃溃疡作用研究
- Author:
Ying-Xin WANG
;
Xiao-Qiang LI
;
Guang-Wu WU
;
Shan-Jun QIAN
;
Hong LEI
;
Chang CAO
;
- Publication Type:Journal Article
- Keywords:
pantoprazole sodium;
experimental ulcer;
gastric acid
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
1999;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Aim To evaluate the effects of pantoprazole on various experimental acute ulcer inrats and mice. Methods The model of a gastric ulcer of rats or mice was caused bystree- induced ulcer and ligatel pylurus-induced ulcer. Results & Conclusions At adose of 5, 10, 20 mg? kg-1 of Pantoprazole can markedly decrease the ulcer index ofstree-induced ulcer. Pantoprazole(4, 8, 16 mg? kg -1 ) significantly decrease the areaof ligated pylorus-induced gastric ulcer. It was also found that pantoprazole caninhibit the output of basic gastric acid.
