Effect of N-methyl berbamine on ATP sensitive K + currents in single ventricular myocytes of guinea pig
- VernacularTitle:N-甲基小檗胺对豚鼠单一心室肌细胞ATP敏感钾电流的影响
- Author:
Jinming LI
;
Shenli ZHANG
;
Guang YANG
;
Qinghuan XIAO
;
Yuping WANG
;
Keyi ZHANG
;
- Publication Type:Journal Article
- Keywords:
N methyl berbamine;
ATP sensitive potassium currents;
ventricular myocytes;
patch clamp technique
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the effect of N methyl berbamine(NMB)on ATP sensitive potassium currents( I KATP )in single ventricular myocytes of guinea pig. METHODS Patch clamp technique with whole cell configuration. Holding potential was -40 mV, commanding potential was -100～+50 mV and duration was 600 ms. Pipette solution contained 0 3 mmol?L -1 ATP. RESULTS NMB inhibited I KATP in a concentration dependent manner. When holding potential was -40 mV and command potential was 0 mV, I KATP were reduced from (0 46?0 09) nA, (0 43?0 15) nA, and(0 47?0 10) nA to (0 37?0 07) nA( n=4,P
