The preparation of type Ⅱ collagen induced arthritis model in mice
- VernacularTitle:小鼠Ⅱ型胶原性关节炎模型的制备
- Author:
Yong JIN
;
Jun LI
;
Yunfang ZHANG
;
Shuyun XU
;
- Publication Type:Journal Article
- Keywords:
tyep Ⅱ collagen(CⅡ);
type Ⅱ collagen induced arthritis(CIA);
delayed type hypersensitivity(DTH)
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
AIM To establish the model of type Ⅱ collagen(CⅡ) induced arthritis in mice. METHODS The type Ⅱ collagen induced arthritits(CIA) mice were induced by intradermal injection with CⅡ and complete Freund adjnvant emulsion. RESULITS In comparison with control mice, the arthritic swelling and index were significant increased. The responses of CⅡ induced delayed type hypersensitivity were remarkably positive, and IgG anti bodies to CⅡ in serum could be detected in CIA mice. CONCLUSION The model CIA mice was successfully established.
