Role of parathyroid hormone and platelet cytosolic free calcium in regulation of blood pressure in uremic patients
- VernacularTitle:甲状旁腺素、血小板胞浆游离钙在尿毒症患者血压调节中的作用
- Author:
Jun ZHANG
;
Xijie LI
;
Youji LI
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Parathyroid hormone Platelet cytosolic free calcium Uremia Hypertension
- From:
Chinese Journal of Nephrology
1997;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
To observe the role of parathyroid hormone PTH( 1 - 84) and platelet cytosolic free calcium I pt[ Ca2 + ] i in regulation of blood pressure on hemodialysis (HD) patients. Methods Fura-2 fluorometry and immunoradioassy werw used to detect PTH(1 - 84) and pttCa2+ ]i in 24 HD patients. Results The resting pt[Ca?+ ]i and PTH(1 - 84) increased in HD cases, and they were significantly higher in uremic patients with hypertension than ones without hypertension. The resting pt[Ca2+ ]i was correlated to PTH( 1 - 84) in HD cases. The multivariate stepwise regression analysis showed the PTH( 1 - 84) and pt[Ca2 + ]i are probably mains factors to affect the blood pressure in HD cases. Conclusion PTH(l - 84) and pt[Ca2+ ji are main factors affecting the blood pressure in uremic patients.
