Protective effect of perindopril on diabetic glomerulopathy in rats with streptozotocin-induced diabetes
- VernacularTitle:Perindopril对糖尿病大鼠肾小球病变保护作用机理的初步探讨
- Author:
Li YAN
;
Rongze YANG
;
Hua CHENG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Angiotensin-converting enzyme inhibitor Diabetic glomerulopathy Renin angiotensin system
- From:
Chinese Journal of Nephrology
1994;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the protective effect of the angiotensin-converting enzyme inhibitor perindopril on diabetic glomerulopathy in rats with experimentally induced diabetes and study its possible mechanisms. Methods Changes of indexes, which include glomerular basement membrane thickness, mesangial matrix volume density, urinary protein excretion rate, plasma and renal tissue renin activity 、angiotensin Ⅱ concentration and renal angiotensinogen mRNA expression level in rats with experimentally induced diabetes, were observed. Results Angiotensin Ⅱ concentration increased in both the renal tissue and plasma in diabetic rats. Perindopril decreased proteinuria and delayed the progression of glomerular basement membrane thickening. However, it did not reduce the expansion of the mesangial matrix ( P
