Influence of photodynamic therapy of endogenous ALA-induced PP Ⅸ on tumor morphological pathology
- VernacularTitle:ALA体内转化PP Ⅸ光动力学疗法对肿瘤细胞形态学的影响
- Author:
Yongling GONG
;
Hongjie LI
;
Hongshe LU
;
Rongchun DONG
;
- Publication Type:Journal Article
- Keywords:
photodynamic therapy;
?-aminolaevulinic acid;
protoporphyrin Ⅸ
- From:
Academic Journal of Second Military Medical University
1982;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the practical photodynamic therapy (PTD) efficiency on tumor of en-dogenous ALA-induced PP Ⅸ. Methods: Morphoraglcal alterations were observed after PDT 0f protopor-phyrin Ⅸ (PP Ⅸ) by application of endogenous 6-aminolaevulinic acid(ALA) in Kunming mice bearing H22hepatic carcinoma. Results: After PDT, the tumor cells showed degeneration, deformation and nuclearnecrosis and the tumor tissues were defused with hemorrhage and necrosis. The ultrastructural pathologyindicated that mitochondria in tumor cells were injured and destroyed. C0nclusi0n: The pathological alter-ations suggest that PDT of ALA on H22 hepatic carcinoma was conducted by the destruction of mitochon-dria.
