Changes of proliferating kinetics in Plasmodium berghei of sodium artesunate-resistance
- VernacularTitle:抗青蒿琥酯钠伯氏疟原虫的增殖动力学改变
- Author:
Ai-Ru LIU
;
Dong-Po ZHAO
;
Zai-Yun SUI
;
Li-Li LU
;
- Publication Type:Journal Article
- Keywords:
plasmodium berghei of sodium artesunate-resistanee;
DNA content;
4' 6-diamidino-2-pheny!indo]e ?2HC1;
fluoromicrospectrophotometer;
proliferating kinetics
- From:
Chinese Pharmacological Bulletin
1986;0(06):-
- CountryChina
- Language:Chinese
-
Abstract:
In the present paper, we measured DNA content of uninuclear Plasrnodium berghei traced with DAPI by means of fluoromi-crospectrophotmeter. The results indicate that the DNA replication of parasite was continuous and it's content was high polyploidy and phase G1 of proliferating cycle was not evident. The dispersion degree of distribution of DNA content in P. R. was markedly lower and the peak sitewas more concentrated and obviously shifted to the right compared with P. N. It was suggested that the speed of DNA replication and proliferating vitality of parasites after producing resistance to SA markedly decreased, indicating that the changes of proliferating kinetics of P. R. happened.
