Effects of ~(60)Co-?-ray and Cyclophosphamide on the Contents of Monoamine Neurotransmitters in Hypothalamus of Rats
- VernacularTitle:~(60)Co—?射线和环磷酰胺对大鼠下丘脑单胺类神经递质含量的影响
- Author:
Chang LING
;
Zhe CHEN
;
Xueqiang HUANG
;
- Publication Type:Journal Article
- Keywords:
~(60)Co-?-ray;
cyclophosphamide;
hypothalamus;
monoamine neurotransmitters;
animal;
rat
- From:
Academic Journal of Second Military Medical University
1985;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The model of rats irradiated by 60Co-?-ray (60Co) or injected by cyclophosphamide (Cy) was studied. It was found that the contents of monoamine neurotransmitters changes greatly in the hypothalamus in both kinds of model. The contents of noradrenalin (NA) and dopamine (DA), and the ratio of DA to DOPAC increased significantly in hypothalamus of rats irradiated by ""Co. The contents of NA and the ratio of 5-hydroxyamine (5-HT) to 5-hychoxyindole acetic acid (5-HIAA) decreased markedly in lamus of rats injected by Cy. The author thinks that there is a certain relation between the of monoamine eurotransmitters and the activity of methylation of NA and monoamine oxidase.
