Comparative effects of Panax notoginseng saponins on hemodynamics of internal carotid artery and superior mesenteric artery in anesthetized rats
- VernacularTitle:三七总皂甙对大鼠颈内动脉、肠系膜前动脉血流动力学的作用比较
- Author:
Jiexiong WU
;
Jiajun SUN
;
- Publication Type:Journal Article
- Keywords:
Panax notoginseng;
saponins;
verapamil;
internal carotid arterial resistance;
mesenteric arterial resistance
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of Panax notoginseng saponins (PNS) and verapamil(Ver)on hemo-dynamics of internal carotid artery and superior mesenteric artery were determined and compared in anesthetized Sprague ~ Dawley strain rats. PNS 30-150 mg ? kg-1 iv was shown to reduce the mean blood pressure, internal carotid arterial resistance and superior mesenteric arterial resistance by 11 % ~19%, 14%~27%,23%~ 39%respectively. Meanwhile, the mesenteric ar-terial blood flow increased.by 16%~51%. Ver showed similar reflects as PNS. The results indicated that the vasodilation effects of PNS and Ver are vascular selective, that is PNS and Ver are more potent in dilating the mesenteric artery than the internal carotid artery.
