Inhibitory effects of calmodulin antagonist EBB on cultured fibroblast
- VernacularTitle:钙调蛋白拮抗剂苄基异喹啉类化合物对培养的成纤维细胞的作用机理研究
- Author:
Weimin LIU
;
Shixuan ZHAO
;
Jie-Wen LIU
;
- Publication Type:Journal Article
- Keywords:
CaM: EBB: DNA ELISA : fibroblast
- From:
Chinese Pharmacological Bulletin
1986;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
Inhibitory effects of the O - ( 1 - ethoxvl - butyl ) berbarmine (EBB) on cultured fibroblast was studied by observating calmodulin (CaM ) content of cultured fibroblast with ELISA and DNA content at each phase of cell cycle with flow - cvtometerv. The CaM con-tent in the test group . compared to control . decreased markedly and DNA content increased significantly in the G0+Gi phase but reduced in the S phase. These results suggested that inhibitory mechanism of EBB on fibroblast proliferation may be closely related to CaM decrease in cells.
