Effects of tetrandrine on pulmonary surfactant activity after inhalation injury in rabbits
- VernacularTitle:粉防己碱对吸入伤家兔肺表面活性物质活性的影响及意义
- Author:
Min ZHANG
;
Ao LI
;
Zongcheng YANG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
burns;
inhalation;
pulmonary surfactant;
pulmonary edema;
tetrandrine;
rabbits
- From:Journal of Third Military Medical University
1983;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The rabbit model of smoke inhalation injury was employed to study the relationship between the decreased activity of pulmonary surfactant and the development of pulmonary edema in inhalation injury and the therapeutic effects of tetrandrine on pulmonary damages.Aftersmoke inhalation injury,the decreased activity of pulmonary surfactant,hypoxemia.hypercapnia,pulmonary inflammation,and pulmonary edema were seen.Tetrandrine could alleviate the pathological manifestations of the lungs,improve hypoxemia and hypercapnia.and protect the surfactant from being destroyed.These findings imply that tetrandrine plays a protective role on the lungs partly due to its protection of pulmonary surfactant from being destroyed.It was suggested that the inhibition of phospholipase Az by tetrandrine might result in the protection of pulmonary surfactant.
