Changes of cardiac ventricles and myocardial and lymphocytic ?-adrenoceptors during and after chronic hypoxia in rabbits
- VernacularTitle:慢性间断缺氧及返回平原后兔双侧心室、外周淋巴细胞?-肾上腺素能受体变化
- Author:
Xinbing MU
;
Zengzhu XIE
;
Junyuan WANG
;
- Publication Type:Journal Article
- Keywords:
anoxemia;
myocardium;
receptors;
adrenergic;
beta;
lymphocytes
- From:Journal of Third Military Medical University
1983;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The dynamic changes of the functions and the weight index of the 2 ventricles and the density of ?-adrenoceptors in the myocardium were observed and the correlation between the changes of ?-adrenoceptors of the myocardium and.the peripheral lymphocytes was investigated during and after intermittent chronic hypbxia in rabbits.The fingings were as follows.(1)Chronic hypoxia resulted in an increase of systolic pressure,dp/dtmas and weight index of the right ventricle.25 days after the restoration of normal oxygen supply,systolic pressure and dp/dtomas of the right ventricle became normal but its weight index remained increased.(2)The density of ?-adrenoceptors of the 2 ventricles was reduced on the 7th,15th and 30th day of hypoxia as compared with that of the control.25 days after the restoration of oxygen supply,the density of ?-adrenoceptors became normal in the left ventricle but remained decreased in the right ventricle.(3)There was a positive correlation between the changes of ?-adrenoceptors in the 2 ventricles and peripheral lymphocytes.The findings suggest that hypoxia-induced hypertrophy of the right ventricle is usually accompanied with a decreased density of its ?-adrenoceptors and thedensity of ?-adrenoceptors of peripheral lymphocytes can reflect the changes of ?-adrenoceptors in the myocardium.
