The effects of prostacyclin on the changes of basic fibroblast growth factor after lung injury in dogs
- VernacularTitle:肺损伤时碱性成纤维细胞生长因子的变化及前列环素的作用
- Author:
Guojian LIU
;
Zhengguo WANG
;
Peifang ZHU
;
- Publication Type:Journal Article
- Keywords:
lung/IN;
lung disease/TH;
gene expression regulation;
fibre-blast growth factor;
prostaglandin X;
DNA;
RNA;
nucleic acid hybridization
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The separation,purification and activity determination of basic fibroblast growth factor (bFGF) with nucleic acid molecular hybridization was described and the changes of bFGF in lung injury treated with prostacy-clin were observed.It was found that bioactive bFGF and bFGF-mRNA could only be found in the injured lung tissues but not in the normal lungs.Administration of prostacyclin could slightly elevate the activity of bFGF and signficantly increase the level of bFGF-mRNA.The findings of this study suggest that there is an increase of bFGF level after lung injury,prostacyclin can influence the expression of bFGF,and bFGF plays an important role in the repair of the injured lung tissues.
