THE EXPERIMENTAL STUDY ON MYOCARDIAL LESION INDUCED BY BOTH SELENIUM AND METHIONINE DEFICIENCY IN RATS
- VernacularTitle:硒和蛋氨酸缺乏对心肌损伤作用的实验研究
- Author:
Xianhui ZENG
;
Yueming CHI
;
Liqing XU
;
Huijuan WAN
;
Xiuli LIU
;
Baifen XU
;
- Publication Type:Journal Article
- Keywords:
selenium methionine myocardium
- From:
Acta Nutrimenta Sinica
1956;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
According to the level of selenium (Se) and methionine (Met) in diet, Wistar rats were randomly divided into 3 groups, group A (normal Se and normal Met); group B (Low Se and normal Met); group C (low Se and low Met). The animals were sacrificed after 8-week feeding. The results showed that the alteration of myocardial ultrastructure was slight in group B. Decreased activities of cytochrome oxidase and succinate dehydrogcnase of myocardial mitochonria and decreased activities of GSH-Px in the blood, heart and liver in group B were observed, as compared with those in group A. But the level of TBA was higher than that of group A.The above mentioned changes in group C were extremely apparent than group A or B, indicating both Se and Met deficiency in diet may concern the etiology of Keshan disease.
