Effects of human fetal hepatic stimulator substance on D-galac-tosamine-induced liver necrosis in rats
- VernacularTitle:人胎肝再生刺激物质对大鼠中毒性肝坏死的治疗作用
- Author:
Ping ZHOU
;
Juzheng XIANG
;
Qifen LI
;
Shiqi DU
;
- Publication Type:Journal Article
- Keywords:
hepatic stimulator substance;
cytosol;
human fetal liver;
toxic liver necrosis;
D-Gal
- From:Journal of Third Military Medical University
1988;0(05):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of human fetal hepatic stimulator substance (h-HSS) and liver cytosol (h-FLC) on the survival rate,the intensity of liver damage,and liver regeneration in rats with liver necrosis induced with D-galactosamine were observed.The physico-chemical properties of h-HSS were preliminarily determined.It was found that both h-HSS and H-FLC could markedly increase the.survival rate of the rats with toxic liver necrosis,significantly decrease the serum level of ornithine carbamoyl transferase and mitochondria aspartic trans-aminase,improve the hepaplastin activity,and elevate the incorporation rate of 3H-thymidine with liver DNA.h-HSS was stable after heated to 95℃ for 30 minutes,and sensitive to trypsin treatment.It demonstrated one major band at 15 000 daltons and 3 minor ones at 24 000,34 000,and 40 000 daltons respectively on sodium dodecyl sulfate-polyacrylamide gel electrophoresis.The relative content of the major band was 47.57%.
