THE MECHANISM OF DILATING VASCULAR SMOOTH MUSCLE BY N-METHYLBERBAMINE
- VernacularTitle:N—甲基小檗胺扩血管作用原理的研究
- Author:
Dali LUO
;
Yunrui GAO
;
Wenhan LI
;
- Publication Type:Journal Article
- Keywords:
N-methylberbamine;
Rabbit thoracic aorta;
antagonist parameter ( pD'~2 )
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The study showed that NMBA could inhibit the rabbit thoracic aorta contractions induced by KC1, CaCl2 and NA, and the pD' 2 values were 3.44, 3.67 and 3.73 respectively. NMBA could also antagonize the extracellular Ca2 + contraction of NA with no effect on the intra-cellular Ca2+ contraction. Comparing with verapamil, the mechanism of NMBA action was inferred to blocking Ca2+ influx during excitation. However, further study will be needed.
