SCANNING ELECTRON MICROSCOPIC OBSERVATIONS ON TEGUMENTAL DAMAGE OF SCHISTOSOMA JAPONICUM TREATED WITH LOWER DOSE PRAZIQUANTEL
- VernacularTitle:低剂量吡喹酮对日本血吸虫皮层损害扫描电镜观察
- Author:
Weineng LIAN
;
Meiyu HUANG
;
- Publication Type:Journal Article
- From:
Chinese Journal of Schistosomiasis Control
1989;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
Schistosoma japonicum were obtained from infected rabbits 24 hours after treatment with lower dose praziquantel (30~40mg/kg). The drug-induced tegu-mental surface alteiations of the worms were studied by rcanning electron microscopy. In comparison with untreated worms, the ultrastructures of oral and ventral suckers in both male and female worms were not affected by praziquantel. Major surface alterations including pronounced swellings, erosions and ulcerations were observed,The results showed that the female worms of S. japonicum and those treated with praziquantel at a dosage of 40 mg/kg were more seriously damaged than the male worms and those treated with praziquantel at other dosages.
