EXPERIMENTAL STUDIES ON THE RESISTANCE TO HYPO-XIA OF TOTAL GLUCOSIDES OF PAEONY ROOT
- VernacularTitle:白芍总甙耐缺氧作用的实验研究
- Author:
Jiasheng ZHANG
;
Yu WANG
;
Yongxiang WANG
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Herb paeony root;
Total Glucosides of Paeony Root (TGPs);
Resistance to hypoxia;
Hypothermic effect.
- From:
Chinese Pharmacological Bulletin
1987;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
Total Glucosides of Paeony Root ( TGPs, 5-40 mg/kg) had a dose-related increasing effect on the survival time of mice under normobaric hypoxia. TGPs (20 mg/kg) had a significant increasing effect on survival time of mice under hypobaric hypoxia & a decreasing effect in the oxygen consumption in mice. TGPs ( 40mg/kg ) decreased the mortality of mice from the acute hypoxia induced by KCN. Increasing effect on the survival time of mice under normobaric hypoxia of TGPs was significantly antagonised by chlortrimeton. The efficacy of TGPs (icv 2.5-5 mg/kg) approximated to that of TGPs (ip 5-40 mg/kg) respectively. It suggested that the effect of TGPs on resistance to hypoxia was produced by central nervous system. The efficacy of TGPs ( icv) was significantly antagonised by chlortrimeton. It was shown that the effect of TGPs was produced by H1-receptor. In the experiment of resistance to hypoxia of TGPs (ip or icv), we measured the change of rectal temperature of mice. The data indicated the positive corr- elation of both effects of TGPs (r=0.58, P
