BIPHASIC ACTION OF BIOTIC ACTIVITOR ON TOAD HEART
- VernacularTitle:生物活性物质对蟾蜍心脏的双重作用
- Author:
Futong ZHANG
;
Wenhui ZHANG
;
- Publication Type:Journal Article
- Keywords:
Norepinephrine;
Acetylcholine;
Potassium chloride;
Calcium chloride;
Positive & negative inotropic effect;
Reverse.
- From:
Chinese Pharmacological Bulletin
1987;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The dose-response reaction of NE, ACh, CaCl2 & KC1 was observed in isolated toad hearts. When the above substances in different concentrations were employed, or the hearts were affected by difference blockers, a biphasic action could be observed. The positive inotropic effect of the substance was inhibited with the presentation of negative inotropic eff ect ,if ? &(or) ? receptor were blocked. The negative inotropic effect of the substance changed into positive, when M1, M2 receptor &(or) Cl- channel were blocked.
