Preliminary immunopathological study in alopecia areata
- VernacularTitle:斑秃免疫病理初步观察
- Author:
Jingzhen ZHANG
;
Et Al
;
- Publication Type:Journal Article
- Keywords:
Alopecia arcala/IM;
Langerhans cells/UL;
T-lymphocytes;
Fluorescent antibody technic
- From:Journal of Third Military Medical University
1984;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Studies of the scalps from 42 patients with alopecia areala are given,using direct immunofluorescence ( DIP).Langerhans cells (LC)and T-lyrn hocytc subsets are observed.There is no significant difference between the number of OKT6 cells and Ia+ cells in the epidermis of all groups and the control.LC is seen in hair-bulb in many patients and most frequently in active stage.The main change of LC in hair follicle is increasing of T6+Ia- cells,not significant of T6+Ia+ cells.Most of the infiltrates around the hair follicles are T( OKT3+) cells.T4+cells number and T4/T8 ratio in active arc larger than in resting and recovering stages.DIF shows 88% of the patients having deposits of C3,IgG,and IgM.This suggests that alopecia areata may be the disorder of immnue associated with cellular and humoral immunity.
