STUDY ON EFFECT OF SKIN PENETRATION ENHANCER AZONE ON THE PENETRATION OF SEVERAL DRUGS THROUGH SKIN
- VernacularTitle:促渗剂Azone对几种药物透皮速率的影响
- Author:
Zilong SHEN
;
Jinyi XU
;
Shengzhao LIN
;
Suzhen GUO
;
- Publication Type:Journal Article
- Keywords:
Azone;
Skin penetration enhancer;
Nitroglycerin;
Nicorandil;
a-Asarone;
Radioactivity tracer
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Azone ( 1桪odeylazacyclohenptan-2-one) is one of the best skin penetration enhancers. It can increase the permeability of skin for some hydrophobic compounds, so that it is possible to be admi-nistrated through skin. The effects of Azone on permeability of skin of a-Asarone, Nicorandil and Nitroglycerin were studied by flow through diffusion cell with radioactivity tracer.The results showed that the different concentrations of Azone gave different enhancement. The penetration of the 3 drugs was enhanced about 1-fold by
