STUDY ON THE PHARMACOKINETIC OF RIFAPENTINE IN VOLUNTEERS
- VernacularTitle:国产新药和福喷丁在人体内药代动力学研究
- Author:
Zhiping FANG
;
Yusheng WANG
;
Fangju YANG
;
ET
;
- Publication Type:Journal Article
- Keywords:
Rifapentine;
Rifandin;
Plasma half life;
Pharmacokinetic;
Hepatic microsomal enzyme
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
The pharmacokinetic study of Rifapentine by daily oral administration for 10d and followed by twice weekly for another 3 weeks in 9 volunteers and in comparism with Rifandin were reported. The results showed that the absorption and excretion of Rifapentine were markedly slower than that of Rifandin, its T1/2 was 15h. The Peak plasma level and T1/2 decreased after repeated administration of the drug. This suggested that Rifapentine and Rifandin in similar to Ri-fampin were hepatic microsomal enzyme inducers.
