EFFECTS OF ANISODAMINE ON HEMOD-YNAMICS & CARDIAC PUMP FUNCTION IN ANESTHETIZED DOGS
- VernacularTitle:山莨菪碱对麻醉犬血流动力学及心泵功能的影响
- Author:
Zuoping REN
;
Minghua LIANG
;
Huazhu ZHOU
;
Al ET
;
- Publication Type:Journal Article
- Keywords:
Anisoda mine;
Hemodynamics;
Cardiac pump function;
Impedance cardiogram;
Systolic time interval
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
Experiments were carried out in 14 closed-chest dogs anesthetized with urethane and chloralose. The tracings of FAP, the 1 st derivatives of cardiac impedance variations ( dZ/dt) , PCG and ECG were recorded synchronously on a SJ-42 Polygraph. CO and STI were determined according to Kubicek and Weissler, respectively.5-10 min after injection of 5 mg/kg wt of anisodamine intravenously, MAP and TPR reduced drastically, accompanied by a slight slowing in HR and a moderate decrease in CO; increased PEP/LVET associated with lengthening of Q-Z interval and reduction of Heather's index. There were significant differences (P
