ANTIBACTERIAL & CYTOTOXICITIC ACTIVITY OF AMETHYSTOIDIN A,RABDOSIA MACROPHYLLA C & THEIR DERIVATIVES
- VernacularTitle:香茶菜甲素、大叶香茶菜丙及其衍生物的抗菌和细胞毒作用
- Author:
Quansheng YAO
;
Guolin ZHOU
;
- Publication Type:Journal Article
- Keywords:
Amethystoidin A;
Rabdosia macrophylla C;
Antibacterial activity;
Cytotoxicity
- From:
Chinese Pharmacological Bulletin
1987;0(01):-
- CountryChina
- Language:Chinese
-
Abstract:
This article reports preliminarily the effects on the antibacterial activity & cytotoxicity of the derivatives of two diterpenoid components, Amethystoidin A & Rabdosia macrophylla C(i.e.Orido-nin ) which were isolated from the medicinal plants of Rabdosia ( Bl. ) Hassk. The experiment demonstrated that diacetate derivative of Amethystoidin A ( n ) could significantly enhance the antibacterial effect being 2 - 3 times more potent than that of Amethystoidin A. Hydrolytic derivative of Rabdosia macrophylla C (V) had a significant increase in the cytotoxicity on heptoma cell (QGY-7703 ) in vitro.
