STUDY OF MECHANISM OF EXCITANT ACTION OF ACHYRANTHES BIDENTATA SAPONINS ON ISOLATED RAT UTERI
- VernacularTitle:牛膝总皂甙对大鼠离体子宫兴奋作用机理的研究
- Author:
He ZHU
;
Xiping CHE
;
- Publication Type:Journal Article
- Keywords:
Achyranthes bidentata Saponin;
Indomethacin;
Chlorpromazine;
Prostaglandin E_2;
Atropine;
Isolated rat uterus
- From:
Chinese Pharmacological Bulletin
1986;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
0.25mg/ml of Achyranthes bidentata Saponins( ABS ) in De Jalon's solution usually caused an obvious excitant action in both virgin and pregnant uterine preparations. The uterine excitation was blocked effectively by prior treatment of the preparations with 20?g/ml of indomethacin for 1 h.In the isolated uterine preparations taken from the rats treated with indomethacin, 15 mg/rat orally twice a day for 2 and a half days, the excitant action of ABS was obviously reduced.Treatment of the uterine segments with 0.5?g/ml of chlorpromazine for half an hour also blocked the excitant response. However, treatment of the uterine preparations with 10?g/ml of atropine for 10 min had no abvious effect on the excitant response. The probable mecha-nism of action of ABS was discussed.
