X-chromosome Inactivation Patterns in Korean Women with Idiopathic Recurrent Spontaneous Abortion.
10.3346/jkms.2004.19.2.258
- Author:
Jin Woo KIM
1
;
So Yeon PARK
;
Young Mi KIM
;
Jin Mee KIM
;
Jung Yeol HAN
;
Hyun Mee RYU
Author Information
1. Laboratory of Medical Genetics, Samsung Cheil Hospital and Women's Healthcare Center, Sungkyunkwan University School of Medicine, Seoul, Korea. ryu97@samsung.co.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Abortion, Spontaneous;
X chromosome;
Receptors, Androgen
- MeSH:
Abortion, Habitual/*genetics;
Abortion, Spontaneous/*genetics;
Adult;
DNA Methylation;
*Dosage Compensation (Genetics);
Female;
Heterozygote;
Human;
Korea;
Linkage (Genetics);
Lymphocytes;
Pregnancy;
Support, Non-U.S. Gov't
- From:Journal of Korean Medical Science
2004;19(2):258-262
- CountryRepublic of Korea
- Language:English
-
Abstract:
Recurrent spontaneous abortion (RSA) defines as two or more consecutive losses at < or =20 weeks of gestation and affects an estimated 1 of every 100 couples wishing to have children. However, it remains a poorly understood phenomenon. Recent reports observed a significant association between highly skewed X chromosome and RSA, supporting that X chromosome inactivation might be an important and previously unknown cause of RSA. X-inactivation pattern, using polymeric X-linked women with idiopathic RSA and 80 control subjects with a single successful pregnancy and no history of spontaneous abortion. The ratio of heterozygotes was 68.2% (45/66) in women with RSA and 67.5% (54/80) in control group. Among 45 informative RSA cases, only 1 (2.2%) woman showed extreme skewed X inactivation (> or =90%) and 4 (8.9%) had mild skewed inactivation (> or =85%). In 54 heterozygous control subjects, 5 (9.3%) women showed extreme skewed X inactivation and 7 (13.0%) had mild one. The frequency of skewed X inactivation between RSA patients and control group was not significantly different (p>0.05). This finding suggests that skewed x romosome be not associated with unexplained RSA patients.
