KINETICS OF SELENIUM UPTAKE INTO PLATELETS, LIVER AND PLASMA OF SELENIUM-DEFICIENT RATS
- VernacularTitle:硒掺入缺硒大鼠血小板、肝及血浆的动力学研究
- Author:
Xiaoshu CHEN
;
Anna XUE
;
- Publication Type:Journal Article
- Keywords:
selenium uptake platelate liver plasma selenium-deficient rat
- From:
Acta Nutrimenta Sinica
1956;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
A one time large dose of selenium with label was injected to Se deficient rats. Platelets, liver and PPP were assayed for GSH-Px activity and determined the uptake of Se. The results showed that platelet GSH-Px activity would also be a good index in reflecting the abrupt change of Se status. It can be changed rapidly and significantly. The results also demostrated that platelet GSH-Px trends to reflect GSH-Px in the liver which is the organ with the most labile Se pool. Platelet GSH-Px may be a suitable index of selenium status for determine the bioavilability of selenium from various food sources in short-term human studies. When different form of Se was given, GSH-Px activity in platelet, liver and PPP expressed on a protein basis was similar in the selenite and selenomethionine administered groups. However, Se uptake of platelet, liver and PPP was greater in the selenomethionine versus the selenite group, indicating that selenomethionine was being taken up nonspecifically into platelet protein other than GSH-Px. This fact was also shown by the lower platelet GSH-Px specific activity. There might be another metabolic way for Se. More work is needed to clarify metabolism of selenium in tissue.
