THE EFFECT OF A NEW CARDIOTONIC AGENT QIANGXINIMIDINE (MD) ON ISOLATED GUINEA PIG ATRIA
- VernacularTitle:强心咪啶对豚鼠离体心房的作用
- Author:
Jian ZUO
;
Shinan WANG
;
Kemin GU
;
- Publication Type:Journal Article
- Keywords:
cardiotonic agent qiangxinimidine guinea pig isolated atria
- From:
Academic Journal of Second Military Medical University
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
The cardiotonic activity of MD, a domestic product of AR-L115, BS, was tested and verified in isolated guinea pig atria, compared with that of isopreraline (ISO). The electrically paced left atria was used to determine their positive inotropic action, while the spontaneously beating right atria was used to determine their positive chrono-tropic action. The results demonstrate: (1) MD showed a strong positive inotropic action comparable to ISO. (2) MD also showed some positive chronotropic action, although this is much weaker than that of ISO. (3) The single dose of MD showed that the positive inotropic action developed quite slowly and strengthened gradually for a long time, while the action of ISO developed so steeply that its peak effect can reached within a few minutes. (4) Propranolol can definitely block both inotropic and chronotropic actions of ISO but scarcely those of MD. This suggests that MD is not a ?1-receptor agonist.The experimental results described above are similar to those reports abroad.
