Changes of Lysosomes of Hepatocytes in Rats Aged One to Ninety Days
- VernacularTitle:生后1至90天大白鼠肝细胞溶酶体的年龄性改变
- Author:
Tian YANG
;
Qimin WANG
;
- Publication Type:Journal Article
- From:Journal of Third Military Medical University
1984;0(02):-
- CountryChina
- Language:Chinese
-
Abstract:
The changes of lysosomes of the hepatocytes in 27 healthy female rats aged 1, 5, 15, 30, 50, and 90 days respectively were observed on morphometry and by studying the ultrastructures with electron microscope. The results are as following:1. The volume density and numerical density of the lysosomes of rat hepatocytes are markedly increased as the age increases.2. The lysosomes originally scattered in cytoplasm gradually migrate to the periphery of bile canaliculi.3. The proportion among certain forms of secondary lysosome changes as the rats grow older and the alteration of autophagic vacuoles is more prominant than others.The significance of the lysosome changes mentioned above was discussed. The author, considering from all the results, suggests that the time around five days after the birth of the rats is a critical period for the development of the lysosomes of rat hepatocytes.
