EFFECTS OF SUPPLEMENTATION OF L-ASCORBIC ACID IN HIGH DOSES ON METABOLISM OF TECHNICAL BENZENE HEXACHLORIDE (BHC) .
- VernacularTitle:高剂量维生素C对六六六代谢影响的研究
- Author:
Yunzhen ZHOU
;
Yixiang SU
;
- Publication Type:Journal Article
- From:
Acta Nutrimenta Sinica
1956;0(03):-
- CountryChina
- Language:Chinese
-
Abstract:
The effects of chronic administration of technical benzene hexachloride on histological pattern of liver and kidney in rat and mixed function oxidase system of liver microsomes were studied. Administration of BHC brought about increase in the liver weight, vacuolar of hepatic cells and hydropic degeneration of the epithelial cells of the renal tubules. Through electromi-croscopic examination, we discovered that there were proliferation and expansion of the smooth endoplasmic reticulum, swelling of the mitochondria in the cytoplasm in the liver cells and kidney cells and increase in the number of lysosome in the epithelial cells of the renal tubles.Administration of BHC stimulated an increase in the tissue storage and urinary excretion of ascorbic acid and induced mixed-function oxidase system of liver microsomes.Supplementation of L-ascorbic acid in high doses under the toxic conditions significantly improved pathological damage of the liver and kidney cells, decreased residuary amount of BHC in the tissue, and facilitated the induction of mixed-function oxidase system of liver microsomes by BHC.
