THE DIRECT ACTION OF SOMAN ON THE NEUROMUSCULAR JUNCTION OF THE ISOLATED RAT'S DIAPHRAGM
- VernacularTitle:索曼对大白鼠膈肌神经肌肉接头的直接作用
- Author:
Shanping YU
;
Chuangui LIU
;
- Publication Type:Journal Article
- From:
Medical Journal of Chinese People's Liberation Army
1981;0(04):-
- CountryChina
- Language:Chinese
-
Abstract:
In the isolated rat's phrenic nerve-diaphragm preparation, 1.5-2.5?10-7M dTC could restore 1.1?10-5'M (2?g/ml) soman-blocked tetany to 40-50% of normal, while ChE remained inhibited. 1.1?10-4M soman could abolish this dTC-restored tetany. The effect of dTC could apparently be inhibited by 1.1?10-(?)M soman given 10 min. before the administration of dTC. In the denervated diaphragm, 1.1?10-(?)M soman could enhance the ACh(5.8?10-(?)M)-induced contraction tension by about 14% owing to its ability of inhibiting ChE. After the inhibition of ChE by pretreatment of soman, the ACh-induced contraction of the denervated diaphragm was decreased by about 30% by 1.1?10-(?)M soman. It is suggested that soman, besides inhibiting ChE, also acts directly on neuro-muscular junctions.
